Celecoxib: Cardiovascular Risk No Worse Than That of Nonselective NSAIDs

Many Minds are No Worse than One

Comparative Risk of Cardiovascular Outcomes Between Topical and Oral Nonselective NSAIDs in Taiwanese Patients With Rheumatoid Arthritis

BACKGROUND Topical NSAIDs have less systemic absorption than oral NSAIDs. We examined the risk of cardiovascular events associated with nonselective topical NSAIDs versus oral NSAIDs among patients with rheumatoid arthritis in Taiwan. METHODS AND RESULTS We conducted a retrospective cohort study that included patients with incident rheumatoid arthritis who were newly starting therapy with non...

Cost-Effectiveness Evaluation of Etoricoxib versus Celecoxib and Nonselective NSAIDs in the Treatment of Ankylosing Spondylitis in Norway

Objectives. To evaluate the cost-effectiveness of etoricoxib (90 mg) relative to celecoxib (200/400 mg), and the nonselective NSAIDs naproxen (1000 mg) and diclofenac (150 mg) in the initial treatment of ankylosing spondylitis in Norway. Methods. A previously developed Markov state-transition model was used to estimate costs and benefits associated with initiating treatment with the different c...

Cardiovascular safety of NSAIDs.

Evidence • Meta-analysis of 754 RCTs (about 350 000 patients)1: -Mixed population, primarily patients with arthritis at low to moderate CV risk (ie, CV event rate about 1% per year). -Use of COX-2 inhibitors compared with placebo increased —all-cause mortality, rate ratio (RR) = 1.22 (95% CI 1.04 to 1.44); and —serious CV events, RR = 1.37 (95% CI 1.14 to 1.66). -Diclofenac (150 mg daily): simi...

Risk of upper gastrointestinal hemorrhage in warfarin users treated with nonselective NSAIDs or COX-2 inhibitors.

BACKGROUND Little is known about the risk of upper gastrointestinal (GI) hemorrhage during the concomitant use of warfarin and selective cyclooxygenase (COX)-2 inhibitors. We examined the association between the concomitant use of warfarin and nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) or selective COX-2 inhibitors in older adults hospitalized for upper GI hemorrhage. METHODS ...